Previous studies with intestinal biopsy specimens from an NPC patient expressing the I1061T mutation have reported an impaired intracellular trafficking and functional deficits of the LR associated proteins sucrase-isomaltase and maltase-glucoamylase, explaining thus the reduced carbohydrate digestion in the intestinal lumen and delineating the effect of deficient cholesterol and sphingolipid homeostasis in development of gastrointestinal symptoms in NPC patients [19]. Here, MGAM is linked to nasopharyngeal carcinoma.