One of these functions is the endothelial nitric oxide synthase (eNOS) that produces NO to assist in gastric ulcer healing mainly through stimulation of the vascular integrity and mucus production, increasing the blood flow, and anti-inflammatory action [27], while excessive NO generated from inducible nitric oxide synthase (iNOS) was involved in the tissue damage via the formation of ROS and the toxic effects on cells [28]. The gene discussed is NOS3; the disease is gastric ulcer.