MCAM and neoplasm: So far, the studies in vivo either inactivating MCAM by antibodies or the silencing of MCAM with plasmid DNA-encoding shRNA against MCAM have shown antitumor and antimetastatic effects, which are sum of the complex and complementary effects, such as the inhibition of proliferation of endothelial and tumor cells, migration, invasion, and antiangiogenic effect in endothelial cells [3,15,21,23,39].