When LDL cholesterol, triglycerides, and apolipoprotein B were assessed together in multivariable MR, only apolipoprotein B (OR 1.92; 95% CI: 1.31–2.81; P < 0.001) retained a robust, potentially causal relationship with CHD (Fig 3A). The gene discussed is APOB; the disease is coronary artery disorder.