On appraisal in a multivariable MR analysis that included apolipoprotein B (which retained evidence of a potentially causal relationship with CHD on mutual genetic adjustment for LDL cholesterol and triglycerides), the effect estimates of both HDL cholesterol and apolipoprotein A-I diminished and were not distinguishable from the null (Fig 3B). The gene discussed is APOB; the disease is coronary artery disorder.