VANGL2 and autosomal dominant polycystic kidney disease: However, we found no renal cysts in mice with collecting duct excision of Vangl2. Furthermore, there is no evidence that PCP-dependent OCD is disturbed prior to cyst appearance in mouse mutants with excision of Pkd1 or Pkd2 in renal tubules (genes mutated in autosomal dominant polycystic kidney disease) [42].