TNF and Alzheimer disease: A previous case-control study of 8.5 million insured adults in the United States (US) reported increased risk for AD in patients with RA and that etanercept, a TNF blocking agent prescribed for the treatment of RA, was associated with reduction of risk for AD (Adjusted Odds Ratio (AOR) = 0.30; 95% Confidence Interval (CI) = 0.08–0.87.