Moreover, sensitization with the inflammatory agent Imiquimod (IMQ), which induces a skin inflammation with common features to psoriasis in an IL-23-dependent manner [2], increased the frequency of IL-23R-expressing TCRγδ cells [27], while inducing a small increase of the CD4+IL-23R+ subpopulation (Fig 5A). This evidence concerns the gene IL23A and psoriasis.