It has been shown that HDAC-1 represses the transcription of SNAI2 in lung cancer cells.19 Indeed, our immunofluorescence data revealed that DAXX overexpression in MKN45 cells led to translocation of HDAC-1 from the cytoplasm to the nucleus, suggesting that DAXX overexpression-induced downregulation of SNAI3 could be mediated by HDAC-1. This evidence concerns the gene SNAI2 and lung carcinoma.