Moreover, the enhanced immunoreactivity of resected GBM tissue for the FTL subunit accounts for the synthesis of a FTL-type isoform, which corresponds well with the reported expression of FTL-type isoferritins in cultured glioblastoma-derived cells,10 and with similar findings in glioblastoma stem-like cells.11 Strikingly, we demonstrate for the first time an apoptosis-stimulating activity of GBM-derived isoferritins. This evidence concerns the gene FTL and glioblastoma.