Albeit the pathophysiological significance of this novel finding is elusive, earlier research has demonstrated that iron-mediated oxidative stress and lipid peroxidation plays a pivotal role in ferritin-mediated apoptosis.12 On the other hand, high cytosolic ferritin levels may confer cytoprotection by enhanced iron sequestration, and affecting stress-associated targets such as the GADD45A/JNK pathway.10 Notably, elevated iron requirements have been demonstrated for glioblastoma stem-like cells where an increased ferritin expression supposedly confers stable intracellular iron buffering.11 This evidence concerns the gene GADD45A and glioblastoma.