Instead of initiating the treatment 1 week after implantation of cells [as was done by Pothula et al.,11] the tumours in this study were allowed to develop for 4 weeks (at which time tumours are well established and have metastasised) and the mice were then treated for 6 weeks with HGF/c-MET inhibitors and gemcitabine as single agent, or in dual or triple combinations. Here, HGF is linked to neoplasm.