We have established the role of MUC4, a high molecular weight mucinous glycoprotein, in motility, invasion and metastasis of pancreatic cancer, thus we focused on MUC4 in the current study.27 Its expression was reduced significantly in FUT3 and MGAT3 KD cells, whereas B3GNT3 KD showed no change in MUC4 protein expression (Fig. 4a–c, S5 E). Here, MUC4 is linked to familial pancreatic carcinoma.