FUT3 participates in O-linked glycan synthesis whereas MGAT3 is an N-linked glycoenzyme.49,50 FUT3 adds the terminal sugar fucose by α1,3 and α1,4 linkage resulting in the formation of sLex and sLea type glycan.51–53 Loss of FUT3 has been implicated in reducing tumour metastases and progression in a variety of cancers.54–56 Zhan et al. found that knockdown of FUT3 in Capan-1 cells decreased proliferation and migration. The gene discussed is MGAT3; the disease is cancer.