Furthermore, since acceptor specificity and reaction kinetic analysis for B3GNT3 is not known, we believe that its loss will result in an exposure of Galβ1,3GalNAc residues on the glycoproteins thus making the action by GCNT1 and GCNT3 more catalytically favourable.36 This contributes to higher sLex synthesis and increased tumour invasion and metastasis (Fig. S5E).8,47 Thus, the findings in our study are in accord with the traditional understanding of the role that B3GNT3 may play in regulating cancer cell migration and metastasis. Here, B3GNT3 is linked to cancer.