Meanwhile, recent emerging evidence has suggested that HLA-I expression loss could result in resistance to anti-PD-1/PD-L1 blockade; nevertheless, the tumour had PD-L1 expression or high TIL infiltration.13,44 In our study, we confirmed the different prognostic implication of CD8+ TIL according to not only PD-L1 but also to HLA-I expression, indicating the important relationship between TIL infiltration, and PD-L1 and HLA-I expression. This evidence concerns the gene CD8A and neoplasm.