Converted cells, miPS-Huh7cm cells, and the tumour-derived primary cells sustained the expression of stemness markers such as Nanog, Sox2, Kif4 and Oct 3/4, which are considered essential for maintaining cell stemness.40 These transcription factors related to pluripotency may also contribute to tumorigenesis.41 On the other hand, the angiogenesis could be one of the differentiation potentials of CSCs resulting in the differentiation into CD31-positive endothelial cells with expression of VEGF-A and VE-cadherin. The gene discussed is SOX2; the disease is neoplasm.