Higher FGA was associated with higher tumour grade (p = 0.002), presence of comedo type necrosis (p = 0.0003), ER negativity (p = 0.009), HER2 positivity (p = 0.0003) and presence of at least one deleterious/missense TP53 variant (p < 0.0001); (Supplementary Fig. 3). Here, TP53 is linked to neoplasm.