There was a slight synergy effect by co-overexpressing HP1β and HP1γ on induction of p53 signaling and inhibition of colony formation of cervical cancer cells (Supplementary Fig. S13A, B, D), while UBE2L3 suppression by HP1γ was not affected by co-expression of HP1β (Supplementary Fig. S13C). The gene discussed is TFF3; the disease is cervical carcinoma.