The observed changes in CRC cell motility and invasiveness following inactivation of TCF7L2 prompted us to analyze potential relationships between the occurrence of TCF7L2 genomic alterations and colorectal tumor progression using publicly available data for colon adenocarcinoma (COAD) from The Cancer Genome Atlas (TCGA) collection. The gene discussed is TCF7L2; the disease is colon adenocarcinoma.