Matching the results of our expression analyses in CRC cell lines, expression of TCF7L2 was anticorrelated to that of RUNX2 and ITGBL1 in CRC transcriptomes (Fig. 6d), whereas a positive correlation existed for expression of TCF7L2 and KLF4. The relationships between expression of TCF7L2 and RUNX2 and their potential targets ITGA3, ITGB7, and LAMB3 were more ambiguous, hinting at indirect and more complex connectivity, possibly depending on the precise cellular context. This evidence concerns the gene RUNX2 and colorectal carcinoma.