RUNX2 and colorectal carcinoma: In contrast, TCF7L2 associated with both RUNX2 intragenic elements in TCF7L2WT cells but not in TCF7L2KO cells (Supplementary Fig. S18b), thereby identifying RUNX2 as a direct target gene that is repressed by TCF7L2 in HCT116 and HT29 CRC cells.