TCF7L2 and colorectal carcinoma: In summary, the physiological functions of TCF7L2 appear to be largely retained during colorectal carcinogenesis: control of proliferation and motility of CRC cells precisely reflect the roles of Wnt/β-Catenin signaling and its nuclear effector TCF7L2 in the healthy intestinal epithelium where they stimulate proliferation of stem and progenitor cells, and control cell migration and allocation along the crypt axis [8, 10, 11, 32, 51].