Expression patterns of TCF/LEF family members in colorectal tumors deviate from the healthy intestinal epithelium and are highly variable, as evident from CRC transcriptome data (Supplementary Fig. S2a, b), and immunohistochemical stainings of case-matched normal and CRC tissue specimens (Supplementary Figs. S3, S4). The gene discussed is HNF4A; the disease is colorectal neoplasm.