However, when the virus-containing siPdcd4 was injected before CRS, the mice would spend significantly more time in the center in the OFT and in the open arms in the EPM compared with those injected with control virus, suggesting that knockdown of Pdcd4 prevented CRS-induced anxiety-like behavior in mice (Supplementary Fig. 10h–j). The gene discussed is PDCD4; the disease is congenital rubella syndrome.