PDCD4 and major depressive disorder: To address the clinical significance of Pdcd4 in major mood disorders in human, we screened the gene expression profiles in the postmortem brain of patients with bipolar disorder, major depression and schizophrenia from the GEO database (GSE42546, GSE53987 and GSE12654), and then analyzed the relation between Pdcd4 expression level and diseases (Supplementary Table 4).