Deficiency for ACC1 also impairs Th1 and Th2 cell development.146 On the other hand, ACC1 deletion in T cells does not affect CD8+ T cell function, even though it enhances cell death and reduces effector T cell expansion in response to bacterial infection.147 These findings suggest that fatty acid synthesis is important for CD8+ T cell persistence. The gene discussed is ACACA; the disease is bacterial infectious disease.