However, there is emerging evidence that LKB1 has AMPK-independent roles in T cell biology, including Treg cell-dependent suppression of autoimmunity and T cell-dependent inhibition of intestinal polyp formation.215,228,237 Thus, the contribution of LKB1 downstream targets in T cell biology and metabolism is an exciting area that requires more exploration. This evidence concerns the gene STK11 and intestinal polyp.