BRAF and melanoma: Following the treatment of B-RAF mutant melanoma with different mitogen-activated protein kinase (MAPK) pathway inhibitors, a stable isotope labeling by amino acids in cell culture (SILAC)-based phosphoproteomic analysis revealed the inhibitor-specific regulation of MAPK kinase 1/2 or extracellular signal-regulated kinase 1/2 and an off-target reaction with p38α and led to the identification of several novel targets in the B-RAF-driven pathway13.