In our study92, bradykinin, ATP, substance P and CGRP levels in BALF were increased in OVA mice, and these increases were augmented in OVA plus UFP-exposed mice and in NHBE cells with increasing UFP doses, suggesting that UFPs activate TRPVs and P2X7 and secrete neuromediators that lead to airway inflammation, exacerbating asthma. The gene discussed is P2RX7; the disease is asthma.