A simple logistic regression analysis revealed that women were 11 times more likely to harbor a diagnosis of primary hypothyroidism (OR, 10.99; 95% CI, 3.13-38.7; P < .001), while patients with TPO antibodies had a 7 times higher likelihood of primary hypothyroidism than their TPO antibody–negative counterparts (OR, 7.36; 95% CI, 1.89-28.6; P = .004) (Table 2). The gene discussed is TPO; the disease is Primary hypothyroidism.