Orthologs of fetuin-A (ahsg1) and ATP binding cassette subfamily B member 11 (abcb11b), liver-expressed genes associated with obesity and metabolic syndrome, were downregulated and upregulated in response to HFHC diet, respectively; however, this transcriptional response was significantly greater in EAE larvae (Figure 6, G and H, and refs. 47–50). This evidence concerns the gene AHSG and obesity due to melanocortin 4 receptor deficiency.