Genes directly associated with adipogenesis and obesity, including growth hormone 1 (gh1) and dehydrogenase/reductase 7 (dhrs7b), were also uniquely dysregulated in EAE larvae in response to HFHC diet (Figure 6, I and J, and refs. 51–53). The gene discussed is DHRS7B; the disease is obesity due to melanocortin 4 receptor deficiency.