Supplementary Figs. 1–4 present a more detailed survival analysis of patients initially staged at cT3/4 N + who received chemotherapy stratified for adenocarcinoma and squamous cell carcinoma and who were downstaged to ypT0N0 (Supplementary Fig. 1), ypT1/2 N0 (Supplementary Fig. 2), ypT1/2 N + (Supplementary Fig. 3), or ypT3/4 N0 (Supplementary Fig. 4). This evidence concerns the gene RAB11B and adenocarcinoma.