A study on invasive pituitary tumors identified that the TNFα network—including genes coding for proteins (TNFα, CCL3, CXCL12, and CCL2), microRNAs (miR-181c-5p and miR-454-3p) and lncRNAs (NR_033258 and lncRNA_SNHG24)—is upregulated in bone-invasive pituitary adenomas compared nonbone-invasive counterparts, suggesting that targeting the TNFα pathway may be beneficial for these invasive tumors (320). Here, TNF is linked to pituitary tumor.