miR-186 targets SKP2, which inhibits expression of p27, a negative regulator of G1 cell cycle progression, increasing proliferation. In human pituitary tumors, miR-186 and p27 expression is downregulated, while SKP2 expression is upregulated (240). In vitro, SKP2 overexpression decreases p27 expression and increases cell growth (240). This evidence concerns the gene CDKN1B and pituitary tumor.