Identification of distinct profiles in subtypes. Using RNA sequencing, 6 distinct transcriptomic profiles have been identified which match the World Health Organization (WHO) 2017 tumor classification (17), with the following discrepancies: (1) null cell subtype matches GT-PTs; (2) silent and secreting ACTH-PTs show distinct profiles; (3) mixed GH-PRL tumors cluster with GH-PTs, rather than PRL-PTs; and (4) sparsely granulated GH-PTs cluster with thyrotroph and plurihormonal PIT1-positive tumors rather than densely granulated GH-PTs. Here, POMC is linked to neoplasm.