MicroRNA 106b~25 cluster shows increased expression in invasive ACTH-PTs and Crooke cell adenomas (261). MiR-106b is upregulated in pituitary tumors and can increase migration and invasion of pituitary tumor cells through the phosphatidylinositol 3-kinase (PI3K)/AKT pathway (262, 263). This evidence concerns the gene PIK3CA and pituitary tumor.