Downregulation of miR-132 and miR-15a/16 with upregulation of SOX5 is seen in invasive tumors (254). MiR-15a and miR-16-1 are also downregulated in pituitary tumors that develop after 12 months of age in mice with heterozygous Men1 knockout (255). MiR-16 expression, which induces apoptosis (via Bax) and decreases proliferation, is reduced in pituitary tumors (256). This evidence concerns the gene MEN1 and pituitary tumor.