ACSS2 and hepatocellular carcinoma: In agreement with the prognostic characteristics of the ACSS1 and ACSS2 enzymes as described above, it was seen in HCC subtype-specific GEMs that iHCC1 tumours favourably expressed ACSS2, iHCC2 tumours ACSS3, whereas iHCC3 tumours ACSS1 for acetate utilisation (Figure 3B).