Furthermore, three of these genes [protein kinase cAMP-activated catalytic subunit alpha (PRKACA), phosphatidylglycerophosphate synthase 1 (PGS1) and cardiolipin synthase 1 (CRLS1)] were identified as MDS nodes in HCC networks but not in non-cancer networks, indicating that inhibition of these genes would not be toxic to normal cells. Here, PRKACA is linked to hepatocellular carcinoma.