On the basis that the ACSS enzymes can generate acetyl-CoA to be used as a substrate for FAB, the authors stratified 361 HCC tumours by ACSS1 and ACSS2 expression level, separately, and found that high ACSS1 expression was linked to hypoxia, suppression of fatty acid oxidation, co-expression with the proliferation-specific transcription factor (TF) Forkhead box M1 (FOXM1) and centromere protein F (CENPF)—the implications of both of which in HCC are already established [60, 61]—and a poor prognosis for the patient. This evidence concerns the gene CENPF and hepatocellular carcinoma.