SOD1 and amyotrophic lateral sclerosis: In particular, AEOL-10150, an octaethyl imidazolium Mn(III) porphyrin, has shown broad-spectrum superoxide dismutase (SOD)-like activity in animal models of amyotrophic lateral sclerosis (ALS), idiopathic pulmonary fibrosis, and nerve agent exposure (Figure 1).25