Nevertheless, a study of PSCA in esophageal cancer showed that PSCA plays a tumor suppressor role by promoting the nuclear translocation of RB1CC1.13 Recently, a genome-wide Association Study (GWAS) in Japan found that PSCA gene loci rs2294008, rs2976392 and other variants were associated with the incidence of gastric adenocarcinoma.14 However, the role of PSCA in GC is still unknown, and the function of PSCA in GC has not been fully explored. The gene discussed is PSCA; the disease is esophageal cancer.