Our finding that when combining breast cancers low in EDNRB expression with the gene coding for ET3 (EDN3) supports this finding; while no significant differences were found with combined EDNRB and EDN1 mRNA expression, we did find that basal cancers with high EDN3 and low EDNRB have better survival (Fig. 5B). This evidence concerns the gene EDN1 and breast cancer.