Analyzing The Cancer Genome Atlas (TCGA) RNASeq exon expression database to compare exons specific for each EDNRB-isoform across breast cancer subtypes revealed no significant differences between subtypes, but all EDNRB isoforms were expressed at significantly higher levels in uninvolved breast tissue compared to breast cancer tissue, in agreement with our breast tumor EDNRB isoform expression results (Fig. 1H). This evidence concerns the gene EDNRB and breast cancer.