Interestingly, while EDNRB expression did not significantly predict patient outcome in liver and ovarian cancer, high EDNRB 436/442 and EDNRB-532 expression predicted improved patient outcome in renal cell carcinoma (Fig. S10), suggesting cancer type-specific effects of EDNRB on patient outcome. Here, EDNRB is linked to hereditary clear cell renal cell carcinoma.