In renal cell carcinoma, both EDNRB-442 and EDNRB-532 are associated with tumors with increased pAKT at S473, while in ovarian cancer, there was only a slight association between EDNRB-442 and pAKT_S473 (Supplementary Fig. S9). This evidence concerns the gene EDNRB and hereditary clear cell renal cell carcinoma.