Dephosphorylation of ERK1/2, PDGFR, and VEGFR by CD148 attenuates downstream pathways to inhibit tumor progression 13, 19, 31, 32, while dephosphorylation of Src and FYN activates them and promotes tumor progression 15, 21, 22, 34. The gene discussed is FYN; the disease is neoplasm.