BCL2 and breast cancer: In a word, our discovered small molecule ZINC20032678 could both target the active sites of the c-Met/PARP-1 and thus inhibiting phosphorylation and recruitment of signaling effectors, the cleaved capase-3 was activated; the expression of Bcl-2 was further inhibited while the expression of Bax was up-regulated, and eventually leading to breast cancer cell apoptosis.