KEGG pathway analysis further highlighted the role of S6K1 in cancer progression (Figure 3D, Supplementary Table S7), in which the depletion of S6K1 could re-express a group of tumor suppressor genes including RASSF5, RASSF6, STAT1, CEACAM1, BNIP3L and SOCS2 (Table 1). Here, RASSF5 is linked to cancer.