ERBB2 and breast cancer: One- year trastuzumab in combination with chemotherapy regimens, such as monotherapy paclitaxel (PH), docetaxel plus carboplatin (TCH) or doxorubicin plus cyclophosphamide followed by docetaxel (AC-TH), has been recognized as the standard of care for early HER2-positive breast cancer patients after the results from several prospective clinical trials6-10.