TGFB1 and colorectal carcinoma: TGF-β has been suggested to activate the Smad signaling pathway and significantly enhances invade and metastasis of tumor cells 42.These results suggest that the TGF-β blockade on CRC may be partly mediated by suppression of the PI3K/AKT signaling pathway in TANs and partly mediated by suppression of TGF-β/Smad signaling pathway in tumor cells.