TNF and neoplasm: In this study, higher levels of NO, H2O2, and TNF-α were shown in TANs in the co-culture system treated with 1D11 when compared with other groups, which is consistent with Mishalian's 10 research, i.e. the anti-tumor TANs in two models of murine tumor, Lewis lung carcinoma and mesothelioma, showed more cytotoxic toward tumor cells with higher levels of TNF-α, NO and H2O2.