CSF2 and neoplasm: The present study shows that inhibition of TGF-β released by CRC tumor cells, on one hand, could induce the N2 phenotype of TANs polarization to N1 phenotype by increasing the cytotoxicity potential of TANs and decreasing the metastasis chemoattractants and immunosuppressive molecules produced by TANs; on the other hand, the inhibition could improve the expressions of GM-CSF and INF-γ in the tumor cells which promotes the activation of TANs.