In order to determine the biological function relevance between FOXA1 and miR-100-5p or miR-125b-5p, we asked whether restoration of miR-100-5p and miR-125b-5p expression by transfection of miRNA mimics (referred to simply as mi100-5p mimic and mi125b-5p mimic) could rescue tumor phenotype changes mediated by FOXA1 in HK1 cells. The gene discussed is FOXA1; the disease is neoplasm.