Furthermore, immunohistochemistry assays showed that RASGRP3 or FOXN3 protein level was increased in xenograft tumor tissues derived from either miR-100-5p or miR-125b-5p silenced HK1 cells (Figure S3).Thus, our data confirmed that RASGRP3 or FOXN3 was bona fide target of miR-100-5p or miR-125b-5p, respectively. Here, RASGRP3 is linked to neoplasm.