FRAT1 and central nervous system cancer: Intracranial tumor volumes of all groups of xenograft mice were increased over time, with most significant result on day 21 of modeling (Fig. 2A and B) The glioma volume of mice-FRAT1-KD was significantly smaller than mice-vector (p<0.05 at day 7; p<0.01 at day 14, day 21); whereas no significant difference in glioma volumes was found between mice-vector and mice-control (Fig. 2B).