The associations between our HCC classification and several critical signatures involved in oncogenesis and progression of HCC were also investigated, including extracellular matrix (ECM) signature, epithelial mesenchymal transition (EMT) signature, TGF-β signature, mismatch repair signature, DNA damage repair signature, angiogenesis signature, cell cycle signature, differentiation signature, mTOR pathway signature, stem signature, and WNT activation signature (Figure 4A and 4B). The gene discussed is TGFB1; the disease is hepatocellular carcinoma.