Aberrant expression of HYAL2 is implicated in diverse pathology, including cardiac and skeletal abnormalities, hematopoietic and platelet dysfunction, cancer, and fibrosis.16, 17, 18, 19, 20, 21 However, many reports indicate that a significant proportion of expressed HYAL2 may be enzymatically inactive; thus the cellular function of HYAL2 and the mechanisms through which HYAL2 dysregulation influences pathology have been previously unclear.14 Here, HYAL2 is linked to cancer.