TF and neoplasm: However, PLT being anucleated cells make them especially suitable for loading nucleotoxic anticancer cells agents; in addition, they expose membrane integrin receptors, such as GPIIb/IIIa, CD62P, and protease-activated receptors [17, 64] which interact with TF-releasing tumour cells [17] and thrombin, leading to TCIPA phenomenon [9, 17, 64] and PLT activation and degranulation.