Regarding the known cooperation between NE and PrRP in the AVP and ACTH release (Maruyama et al. 2001; Uchida et al. 2010), as well as in habituation to chronic stress (Toth et al. 2008), we assume that PrRP acts synergistically with NE in the different responses to chronic hypernatremia. The gene discussed is POMC; the disease is Hypernatremia.