PRLH and Hypernatremia: Based on the above facts, we addressed the following questions: 1, whether the level of the stress caused by chronic hypernatremia may depend on the type of hypernatremia (i.e., eu- or hypervolemic, congenital or acquired); 2, whether the different types of chronic hypernatremia affect the responsiveness to acute restraint differentially; and 3, whether the expression of TH, PrRP and nesfatin in the cDMM and cVLM reflects the actual sensitivity of the HPA axis to acute restraint under chronic hypernatremic conditions.