Next we showed in immunodeficient mice xenograft models that METTL8 KO HCT116 cells (Figure S3E) and their mutants, METTL8ΔSAM and METTL8K80R, are less tumorigenic than their wild-type counterpart (Figure 6B) and their difference in tumor volume is deemed to be significant (Figure 6C, n = 4, ∗∗p < 0.01, ∗∗∗p < 0.005). The gene discussed is METTL8; the disease is neoplasm.