METTL8, a member of a group of methyltransferase-like proteins, is originally identified as a tension induced protein (TIP) that is involved in mesenchymal to adipose tissue transition (Badri et al., 2008, Jakkaraju et al., 2005); it is also found to be mutated in colon cancers (Yeon et al., 2018) and regulates mouse embryo stem cell differentiation (Gu et al., 2018). Here, METTL8 is linked to malignant colon neoplasm.