METTL8, a member of a group of methyltransferase-like proteins, is originally identified as a tension induced protein (TIP) that is involved in mesenchymal to adipose tissue transition (Badri et al., 2008, Jakkaraju et al., 2005); it is also found to be mutated in colon cancers (Yeon et al., 2018) and regulates mouse embryo stem cell differentiation (Gu et al., 2018). Here, METTL8 is linked to colonic neoplasm.