LEP and diabetes mellitus: Left ventricular mass was lower (p = 0,008 in model adjusted for age and BMI and p = 0,004 in model adjusted for age, BMI, diabetes, coronary heart disease, systolic blood pressure, antihypertensive medication, glomerular filtration rate, and smoking status) and diastolic wall strain was higher (p = 0,004 and 0,007, respectively).The same influence of leptin was observed in men but was not statistically significant [28].