Since it was reported that TSPO-based PET findings in chronic, but not early, brain disease reflect a proinflammatory state [35, 36], it seems theoretically possible that lower cerebral metabolism couples with higher proinflammatory responses, i.e., [18F]FDG SUVR could negatively correlate with [11C]DPA713 BPND. The gene discussed is TSPO; the disease is brain disorder.