The frequency of genotype identified that all seven of the NEIL1 genetic polymorphisms (rs4462560, rs7182283, rs7402844, rs5745920, rs8030014, rs11634109 and rs79244935) and the NEIL2 rs8191613 genetic polymorphism were not associated with the risk of CIN III and CSCC. The gene discussed is NEIL1; the disease is skin squamous cell carcinoma.