Therefore, in our large-sample population-based study, we selected seven SNP loci in NEIL1 and three SNP loci in NEIL2, then investigated their genotype frequency in 400 cervical squamous cell carcinomas (CSCC), 400 cervical intraepithelial neoplasias (CIN III) and 1200 normal healthy controls, and analyzed the association between these SNPs in the NEIL1 and NEIL2 genes and susceptibility to CSCC and CIN III. The gene discussed is NEIL1; the disease is cervical squamous cell carcinoma.