Several cell lines, such as COLO320DM (colon cancer) and SKOV3 (ovarian), cluster near UWB1.289 + BRCA1 and demonstrate a drug sensitivity signature similar to the BRCA1-restored cell line, whereas OCUBM (breast cancer) and CAOV3 (ovarian) behave like BRCA1-deficient UWB1.289. The gene discussed is BRCA1; the disease is breast carcinoma.