Recent studies have shown that other proteins could also be used as sensitive and specific markers for hepatitis as well as for HCC including the Golgi protein 73 (GP73); which is also named Golgi phosphoprotein 2 “GOLPH2, the Dickkopf-1(DKKpf-1 or DKK-1), and Midkine (MDK). This evidence concerns the gene MDK and hepatocellular carcinoma.