In line with the observed high IL1A/B mRNA and secreted protein levels by metastatic breast cancer cells (Fig. 5a and Supplementary Fig. 9a), treatment with CM from MDA-LM2 or SUM-LM1 cancer cells induced a stronger upregulation of CXCL10 in MRC-5 fibroblasts compared to CM from parental cell counterparts (Fig. 5d). This evidence concerns the gene IL1A and breast cancer.