In experiment 2 (Fig. S9) there was a significant correlation seen at 7 days after oHSV treatment between reduced tumor volumes and increased intratumoral numbers of GP33+ CD8+ T cells (p = 0.007), gB498+ CD8+ T cells (p = 0.007), CD4+ T cells (p = 0.032), as well as reduced numbers of M-MDSCs (p = 0.015). This evidence concerns the gene CD4 and neoplasm.