CD4 and neoplasm: Taking all three experiments together, there was a significant correlation after oHSV treatment or vehicle treatment between lower tumor volume and increased numbers in GP33+ CD8+ T cells (p < 0.001), gB498+ CD8+ T cells (p = 0.001) pan-CD4+ T cells (p = 0.019), but not pan-CD8+ T cells (p = 0.891) (Fig. 5).