Table 3 compares the pregnancy outcomes of the two groups to whom G-CSF was administered and not administered, with five and two twin pregnancies observed in the G-CSF group and the control group, respectively, these pregnancies resulted in miscarriage(fetal loss before 20th weeks of gestation) and early premature birth(birth between 20–28 weeks of gestation). Here, CSF3 is linked to spontaneous abortion.