In a model of bleomycin-induced acute lung injury (ALI), Carey et al. showed that TNC KO lungs were protected from fibrosis, with less SMA + myofibroblasts in the lung, and TNC inactivation prevented constitutively active TGFβ to induce the differentiation of fibroblasts into myofibroblasts19. The gene discussed is TNC; the disease is acute lung injury.