This is supported by the recent study of Lai et al. which described in hepatic stellate cells and hepatocellular carcinoma cells a positive-feedback loop where SCD enhances Wnt signaling through Lrp5 and Lrp6 stabilization and is itself regulated at the transcriptional level by Wnt signaling, contributing to hepatic fibrosis and tumor growth42. This evidence concerns the gene LRP5 and neoplasm.