LRP5 and hepatocellular carcinoma: This is supported by the recent study of Lai et al. which described in hepatic stellate cells and hepatocellular carcinoma cells a positive-feedback loop where SCD enhances Wnt signaling through Lrp5 and Lrp6 stabilization and is itself regulated at the transcriptional level by Wnt signaling, contributing to hepatic fibrosis and tumor growth42.